LIPO-DOX for Platinum-Resistant Ovarian and Fallopian Tube Cancers and Primary Peritoneal Adenocarcinoma

The majority of epithelial ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma (PPA) patients experience disease recurrence even though they receive standard treatment. The treatment outcome after recurrence depended on the interval time between the time to complete platinum-based chemotherapy until the time to replapse that we called a platinum-free interval. In patients with recurrence with a platinum-free interval of more than six months, the retreatment with platinum-based combined regimens are preferred with the nearly 50% response. However, when the interval time was shorter than six months or tumor progression was identified while receiving the platinum-based regimen, commonly known as platinum-resistant and refractory group , the treatment outcome with various chemotherapies in the literature was nearly ten percent (Bast and Markman, 2010; Markman, 2011). One of the anti-neoplastic agents given in platinum resistant patients is pegylated liposomal doxorubicin (PLD). This drug is composed of doxorubicin which is encapsulated in a novel proprietary bilayer lipid sphere